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Antimalarial agent 1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W009109
    Antimalarial agent 1

    		Parasite Infection
    Antimalarial agent 1 is a potent antimalarial agent .
    <em>Antimalarial</em> <em>agent 1</em>
  • HY-114197
    Antimalarial agent 14

    		Mitochondrial Metabolism Parasite Infection
    Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .
    <em>Antimalarial</em> <em>agent</em> 14
  • HY-111529A
    Tafenoquine Succinate
    4 Publications Verification

    WR 238605 (Succinate)

    		 Parasite Infection
    Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .
    Tafenoquine Succinate
  • HY-108640A
    HLI373 dihydrochloride

    		MDM-2/p53 Parasite Apoptosis Infection Cancer
    HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .
    HLI373 dihydrochloride
  • HY-111529
    Tafenoquine

    WR 238605

    		 Parasite Infection
    Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .
    Tafenoquine
  • HY-108640
    HLI373

    		MDM-2/p53 Parasite Apoptosis Infection Cancer
    HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .
    HLI373
  • HY-108251
    Methotrexate metabolite
    1 Publications Verification

    DAMPA

    		 Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite Infection Inflammation/Immunology
    Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent . Methotrexate metabolite is an antimalarial agent, which inhibits the parasite growth with an IC50 of 446 nM against the antifolate-sensitive strain and 812 nM against the highly resistant strain under physiological folate conditions. Methotrexate metabolite is inactive against mammalian cells. Methotrexate metabolite is a minimal inhibitor of dihydrofolate reductase among metabolites of methotrexate .
    Methotrexate metabolite
  • HY-147850
    JMI-346

    		Parasite Infection
    JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ S (3D7; IC50=13 µM) and CQ R (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .
    JMI-346
  • HY-106005
    MMV390048
    2 Publications Verification

    		 Parasite PI4K Infection
    MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kd app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .
    MMV390048
  • HY-147849
    JMI-105

    		Parasite Infection
    JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ S (3D7; IC50=8.8 µM) and CQ R (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent .
    JMI-105

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